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KMID : 0380319750150000283
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Journal of Korean Research Institute for Better Living
1975 Volume.15 No. 0 p.283 ~ p.300
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Study on the Seconary Metabolites of Dactylomyces thermophillus
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Abstract
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Terremutin, terreic acid, and terrein were obtained from Dactylomyces thermophillus. When D. thermophillus was grown on a medium consisting of soybean meal, dextrose, yeast extract, K_2HPO_4 and NaCl under well shaken condition, a large quantity of terremutin was accumulated at an earlier stage of growth, and the compound was transformed to terreic acid at a later stage. On the other hand, terremutin and terrein were accumulated under relatively less shaken condition. When the microbe was grown on another medium consisting of peptone, dextrose, yeast extract and KH_2PO_4, terrein was accumulated. The microbe was also grown well on a mineral dextrose media consisting of (NH_4)_2SO_4, MgSO_4, K_2HPO_4, KH_2PO_4, CaCO_3, dextrose and yeast extract. However, none of those compounds were accumulated.
On the basis of U.V absorption spectral analysis for metabolites accumulated in culture broth, a revised biosynthetic pathway of terreic acid was postulated.
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